An Artificial Safranine Enzyme which Activates Chemotherapeutic Prodrugs
نویسندگان
چکیده
منابع مشابه
Enzyme-catalyzed activation of anticancer prodrugs.
The rationale fo the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the drug itself. In the last decades, numerous prodrugs that are enzymatically activated into anti-cancer agents have been developed. This review describes the most important enzymes involved in prodrug activation notably with respect to tissue distr...
متن کاملProdrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy)
This review focuses on the prodrugs used in suicide gene therapy. These prodrugs need to satisfy a number of criteria. They must be efficient and selective substrates for the activating enzyme, and be metabolized to potent cytotoxins preferably able to kill cells at all stages of the cell cycle. Both prodrugs and their activated species should have good distributive properties, so that the resu...
متن کاملRacemiase, an enzyme which catalyses racemization of lactic acids.
SO-CAETID fermentation lactic acids are generally believed to be inactive, since it was ascertained by Phelps & Palmer [1917] and Pederson et al. [1926] that optically inactive lactic acid was produced in many natural fermentations. The lactic acid in Sake was found to be the inactive form, although not only inactive lactic acid-producing organisms (Lactobacillus sake), but also optically activ...
متن کاملMedication Errors in Administration of Chemotherapeutic Agents: an Observational Study
Chemotherapy medication errors may lead to potentially harmful consequences while most of them could be preventable. This study aims to determine the incidence and type of drug handling and administration errors among the nurses and to identify possible contributing factors. Setting of the study was a teaching hospital affiliated to Shahid Beheshti University of Medic...
متن کاملAn Overview of Asparaginase Enzyme Features: An Anticancer Enzyme with High Potency
Introduction: One of the important findings in the pharmaceutical and medical industry is the use of the asparaginazase enzyme as an anticancer drug. The asparaginase enzyme, hydrolyzing the amino acid of asparagine, reduces this amino acid in the blood and causes the death of cancer cells. Today, the enzyme is used to treat various types of leukemia, particularly acute lymphoblastic leukemia, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.1155